G.R.I.D. (Global Researchers in Dialogue)

KIAT US Office 에서 지원하는 글로벌 연구자들과의 대화 시리즈 입니다. 한-미 산학연 간의 네트워크를 구축하고, 공동 R&D를 희망하시는 분들의 많은 참여를 부탁드립니다.  

This is a series of Dialogue supported by the KIAT US Office with global researchers. We invite everyone interested in building networks between Korean and U.S. academia, industry, and research institutes, as well as those seeking joint R&D opportunities, to actively participate.

Metabolic reprogramming of cancer cells for their survival and metastasis

이번 웨비나에서는 존스홉킨스 대학의 Sangmoo Jeong 교수가 암세포가 불리한 미세환경과 스트레스 상황에서도 생존하고 전이를 촉진하기 위해 대사를 재편하는 메커니즘과, 이러한 과정이 어떻게 치료 표적으로 이어질 수 있는지를 소개할 예정입니다. 특히 전이성 유방암에서 E-cadherin 양성 세포가 세린 합성 경로를 활성화해 산화환원 균형을 유지하고 전이 과정에서의 생존과 증식을 가능하게 하는 원리를 설명할 예정이며, 또한 급성골수성백혈병(AML)에서는 venetoclax 치료가 세린 대사 의존성을 증가시키는 점에 주목하여, 식이 세린 제한과의 병용 전략이 치료 효과를 높일 수 있음을 최신 연구 결과를 통해 제시할 예정입니다. 

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Webinar

 Thursday, May 7, 22:00 (EST)

 5월 8일, 금요일, 오전 11:00 (한국) 

Dr. Sangmoo Jeong 

- Assistant Professor of Chemical & Biomolecular Engineering at Johns Hopkins University

- NIH K99/R00, MIRA awardee; research on cancer and vascular diseases using engineering approaches

Webinar Abstract

Metabolic reprogramming enables cancer cells to survive hostile microenvironments, adapt to stress, and support metastatic progression. Beyond fueling growth, these adaptive programs regulate redox homeostasis, cell fate, and therapeutic response. In this webinar, Dr. Jeong will present recent work showing how metabolism drives cancer progression and creates therapeutic vulnerabilities. In metastatic breast cancer, his group found that E-cadherin-positive cells upregulate the de novo serine synthesis pathway (SSP) to maintain redox balance and anabolic metabolism, enabling survival during metastatic stress and outgrowth after colonization. In acute myeloid leukemia, they identified serine metabolism as a vulnerability in venetoclax-treated cells: venetoclax impairs mitochondrial metabolism and reduces serine synthesis flux, rendering AML cells more dependent on exogenous serine. Accordingly, dietary serine restriction synergized with venetoclax in mouse models to reduce leukemic burden and extend survival. Together, these findings identify metabolic adaptation as both a driver of cancer fitness and a targetable liability.

Speaker

Dr. Sangmoo Jeong is an Assistant Professor in the Department of Chemical &

Biomolecular Engineering at Johns Hopkins University. His lab is interested in applying engineering principles to investigate cancer and vascular diseases and develop novel analytical tools to address challenging questions. He received a Bachelor of Science degree in Electrical Engineering from the KAIST in Korea and a Master of Science and a Ph.D. in Electrical Engineering from Stanford University. He completed his postdoctoral research at Mass General Hospital, and later, Memorial Sloan Kettering Cancer Center. He has received multiple awards, including the NIH K99/R00 and MIRA awards, the CDMRP Idea Discovery Award, and the Emerging Junior Investigator Award from the Korean Institute of Chemical Engineers.